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International Journal of Technology Enhancements and Emerging Engineering Research (ISSN 2347-4289)
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IJTEEE >> Volume 1 - Issue 4, November 2013 Edition



International Journal of Technology Enhancements and Emerging Engineering Research  
International Journal of Technology Enhancements and Emerging Engineering Research

Website: http://www.ijteee.org

ISSN 2347-4289



Electrochemical, invivo and invitro study of Acyclovir and Co(II) Complex

[Full Text]

 

AUTHOR(S)

Deepa Thakur, Jyotsna Mishra

 

KEYWORDS

Keywords : Acyclovir, Electrochemical study, Spectroscopic, Metal complex, Microbial, Pharmacological studies

 

ABSTRACT

ABSTRACT: The antibiotic drug 2-amino-1,9-dihydro-9-(2-hydroxyethoxy)methyl)-6H-purin-6-one has been quantitatively and qualitatively analysis by polarographic & amperometric process. Acyclovir give well identified wave in 1.0mkcl at pH5.00.2.Co (II)-Acyclovir complex studied in aqueous phase..The IR spectral data on the drug & its Co (II) complex indicate the co-ordination through nitrogen atom of azid group. The data showed a shift bands of azide group in complex from1634 cm 11651-cm-1.Hence the tentative structure of the complex has been suggested. The antibiotic activity of the complex has been determine by using paper disc method against Streptococcus A ,K. Pneumonia, Salmonella. Typhi, and Aspergillus. A ,etc .Looking at this inhabitation power against the different test pathogens..It presumed that the complex may be more potent at compare to the parent drug .Pharmacological study shows the toxicological or non toxicological study of complex drugs

 

REFERENCES

[1]. Williams D R, The Metal of Life (Van Nostrond,London),1971

[2]. Kischer S J ,Med Chem,36(1996)9.

[3]. L.I.Antropor Theoretical Electrochemistry Mir publishers Moscow,P433,1972

[4]. A.J Fry Laboratory Tech .in Electro Analytical Chem.2nd Ed.New York 1996

[5]. Y.X.Furet,J.Deshusses, and J.C. , Pechere, Antimi-crobial.Agent Chemother.36(1992) 2506-2511

[6]. Dayer F P and Miller, Chelating Agent and Metal Chelates (Academic press, London)383,1964

[7]. Shukla J. and Pitre KS. Role of Biometal Fe(III) in anticancer effect of Dacarbazine 1998; 42(2): 223.

[8]. Ghosh M N,Fundamentals of experimental pharma-cology, 2nd ed(Scientific Book Agency,) 1984,pp.153

[9]. Lingane JJ. Interpretation of the Polarographic Waves of Complex Meta Ions. Chem Rev 1941; 29(1):1-35.

[10]. I.Turel,I Leban and K.Gruber,J.Inorg.Biochem,1996,63,41.

[11]. O.L.Davies, J.Raventos and A.L.Walpole, B.V.J. Pharmacol, 1946, 1255

[12]. Glans, A, Ehnbom,c.de knock,A. martinz.J. Estrada, et. al. Ruthenium II arene complex with chelating-chloroquine analogue ligands: synthesis, characterization and in vitro antimalarial activity. Dalton trans.2012; 41: 2764-2773.